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يعتبر العصب الخامس مسؤولًا عن نقل الأحاسيس من معظم أجزاء الوجه، بما في ذلك الجبهة، العينين، الأنف، والفك. كما ينقل الإحساس من أجزاء من الفم والأسنان والأغشية المخاطية للفك العلوي والسفلي. ينقسم العصب الخامس إلى ثلاثة فروع رئيسية:
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الفرع الفكي العلوي (Maxillary Branch): ينقل الإحساس من الخدين والفك العلوي والأسنان العلوية.
الفرع الفكي السفلي (Mandibular Branch): ينقل الإحساس من الفك السفلي، ويحتوي أيضًا على ألياف حركية تتحكم في عضلات المضغ.
من أبرز الحالات المرضية المرتبطة بالعصب الخامس هي ألم العصب الثلاثي التوائم، وهو اضطراب يسبب ألمًا شديدًا في الوجه يشبه الصدمة الكهربائية وي
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