Hydrocodone, sold under the brand name Hysingla among others, is an opioid used to treat severe pain of a prolonged duration, if other measures are not sufficient. It is also used as a cough suppressant in adults. It is taken by mouth. Wikipedia Molar mass: 299.368 g/mol Formula: C18H21NO3 Onset of action: 10–20 minutes Other names: Dihydrocodeinone, hydrocodone bitartrate Duration of action: 4–8 hours Trade name: Hysingla ER, Zohydro ER, others People also search for: Oxycodone, MORE Uses. This combination medication is used to relieve moderate to severe pain. It contains an opioid (narcotic) pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). Hydrocodone works in the brain to change how your body feels and responds to pain. Acetaminophen can also reduce a fever.