It is available in all types of variants? yes, then visit Healthetive Pharmacy. It is the best pain relief medication without a prescription. Vicodin is a prescription medication to used { relieve moderate to severe pain }. It is a combination of hydrocodone and acetaminophen and is available in both immediate-release and extended-release tablets. Vicodin works by blocking pain signals from reaching the brain and altering the way the body responds to pain.