Risks and Precautions of Codeine: Like all benzodiazepines, Codeine come with a risk of dependence and withdrawal symptoms, especially when used for a prolonged period or at high doses. Misuse of Xanax can lead to overdose, addiction, or even death. It's crucial to follow the prescribing doctor's instructions closely and to be aware of the potential for interactions with other medications, particularly those that depress the central nervous system, such as opioids and alcohol.