Sildenafil Dosage is a powerful selective cycloguanosine monophosphate (cGMP) inhibitor, a specific phosphodiesterase type 5 (PDE5). The implementation of the physiological mechanism of erection is associated with the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. This, in turn, leads to increased cGMP levels, subsequent relaxation of the smooth muscle tissue of the corpus cavernosum, and increased blood flow. Take this high-dosage effective solution with your doctor’s prescription to handle ED.