Methadone tablet 10 mg available from Safe Online Pharmacy. By connecting to opioid receptors in the brain and spinal cord, the 10 mg methadone pill modifies how pain is perceived. People with moderate to moderately severe pain may find that their quality of life is improved when they take a 10 mg methadone pill. Methadone pills (10 mg) would usually be consumed orally, with or without a meal. Another possible negative effect of a 10 mg methadone pill includes feeling sick, throwing up, constipation, and dizziness. So, without the guidance of your physician, you can not take it as recommended.