10 mg methadone pill from Secure Online Pharmacy. The 10 mg methadone pill operates by binding to opioid receptors in the brain and spinal cord, altering pain perception. When taking a 10 mg methadone pill, it can help improve the quality of life for individuals experiencing moderate to moderately severe pain. It is typically recommended to take 10 mg of methadone pills orally, with or without food. A 10 mg methadone pill can also cause side effects such as nausea, vomiting, constipation, and dizziness. So, you can take it properly with the proper guidance of your physician.