The question "How long does Oxycodone stay in your system?" is frequently asked worldwide. Oxycodone is an FDA-approved opioid medication for chronic back pain, used for injury, trauma, surgery, and cancer. It is available in various dosages and is used for various purposes, including legal and medical tests. Oxycodone's half-life varies among individuals, with a 3.2-hour half-life, varying from 4.5 to 5.6 hours. Factors affecting drug processing include dosage, metabolism, body size, age, and test type. Half-life varies between 3 to 5 hours, affecting liver and kidney health.