Methadone is a medication that is used for the treatment of opioid use disorder (OUD).Methadone is also used for relieving strong internal pain like cancer pain, nervous system pain, and brain pain. Never use methadone with alcohol, other drugs, or other medicines.It may be harmful for you or cause death. Methadone is a highly addictive drug.So, it is too hard to quit using it on your own.If you ever miss any dose, then take it within 8–12 hours as soon as possible. You can use methadone with or without food. Never use this medicine with broken or crushed.