:Lortab is used to relieve moderate to severe pain. Lortab contains a combination of acetaminophen and hydrocodone. It is an opioid pain medicine. An opioid is sometimes called a narcotic.You should not use Lortab if you get allergic.Be sure your doctor knows if you also take medicine for depression, mental illness.Take Lortab exactly as prescribed.Lortab is taken as needed, you may not be on a dosing schedule.Avoid this medicine while driving machinery.