Vicodin 5-500 mg is a prescription pain medication that combines hydrocodone bitartrate (5 mg), an opioid pain reliever, with acetaminophen (500 mg), a non-opioid pain reliever. It is used to treat moderate to severe pain and works by affecting the brain's pain receptors. Due to its opioid content, Vicodin has a potential for addiction, misuse, and dependence, so it should be taken only as prescribed by a doctor.