If you are interested in exercising while taking Hydrocodone, it is important to take certain precautions to ensure your safety. so know thoroughly about several effects. Hydrocodone can have several effects on exercise, which may make it difficult for some people to exercise safely while taking the medication. Some of the effects of Hydrocodone on exercise include: Drowsiness and fatigue: Hydrocodone can cause drowsiness and fatigue, which may affect your energy levels and ability to exercise.