Best Hydrocodone or Order Hydrocodone Online from Nuheals.com Pharmacy and understand that Hydrocodone is Administered on an empty stomach, at least 1 hour prior to or 2 hours after eating. Symmetrical, every 12 hour dosing is appropriate for the majority of patients. Hydrocodone comes as an extended-release (long-acting) capsule and an extended-release (long-acting) tablet to take by mouth. The extended-release capsule is usually taken once every 12 hours. The extended-release tablet is usually taken once daily. Take Hydrocodone at around the same time(s) every day.