By interacting with opioid receptors in the brain and spinal cord, Roxicodone lessens the sense of pain. Roxicodone is the brand name for oxycodone, a class of opioid painkillers used to relieve moderate to severe pain. Like other opioid medicine , Roxicodone has the potential to become a habit, and misuse or excessive usage can lead to addiction, overdose, and death. Most of the time, a doctor or other healthcare provider will only write a short-term prescription for it.