A sibutramine tablet is usually taken once daily followed with doctor instroction. This tablet is taken with and without food. These tablets affect chemicals in the brain that affect weight maintenance. sibutramine tablet used together with diet and exercise to treat obesity that may be related to diabetes, high cholesterol and high blood pressure. sibutramine may also be used for other purposes not listed in this medicaton guide. Tell you doctor precption and over counter medication you use if you do not lose at least four pounds after taking the medication for four weeks along with a low calorie diet.