Meridia assist with weight-loss by alterning neurotransmitter within the brain and is used along with a low calorie diet to help people and weight loss. Doctor advised the starting dose 15 mg meridia dose above 15 mg daily not recommended.side effect flu symptoms runny cough headache back pain skin rash . Meridia may interact with other medicine that makes you sleepy. Meridia affect chemicals in the brain that affect weight maintenance.