Hydrocodone M 365 is a prescription medication commonly used for managing moderate to severe pain. It is an opioid analgesic that combines hydrocodone bitartrate (a pain reliever) with acetaminophen (a non-opioid pain reliever and fever reducer). The M 365 pill specifically contains 5 mg of hydrocodone bitartrate and 325 mg of acetaminophen. It works by affecting the brain and nervous system to reduce pain perception. This medication should be taken as directed by a healthcare provider due to its potential for dependence and misuse.