Rozerem is a prescription medication used to treat insomnia, specifically difficulty with falling asleep. It contains the active ingredient ramelteon, a melatonin receptor agonist that mimics the action of the natural sleep hormone melatonin. Rozerem helps regulate the sleep-wake cycle, promoting the onset of sleep without causing dependence or significant next-day drowsiness. ROZEREM 8 mg & ROZEREM 16 mg.