Prescription Requirement: Hydrocodone acetaminophen 5-325 is a controlled substance and requires a prescription from a licensed healthcare provider. Dosage: The typical dose is 5 mg of hydrocodone and 325 mg of acetaminophen, but the exact dosage and frequency should be determined by a healthcare provider. Patients should use Hydrocodone medications exactly as prescribed by their healthcare provider and be aware of the potential side effects and risks associated with prolonged use.