The M365 pill is a prescription medication prescribed for the management of moderate to severe pain. It is a combination medication containing hydrocodone, an opioid pain reliever, and acetaminophen, a non-opioid pain reliever. Hydrocodone works by altering the body’s perception and response to pain. However, it’s important to note that like all opioids, M365 can lead to tolerance, physical dependence, and addiction, known as opioid use disorder.