$~Hydrocodone Acetaminophen 5 325 efectos secundarios #2024 | Hydrocodone is an opioid. It attaches to certain mu-opioid receptors in your brain to lower how much pain you feel.nAcetaminophen is an analgesic. It blocks the production of certain chemicals in your brain that play a role in pain. As a result, acetaminophen helps relieve pain.