Norco is a prescription medication that combines two powerful ingredients: hydrocodone and acetaminophen. Hydrocodone is an opioid pain reliever that works by affecting the signals in the brain and nervous system that tell you what pain is. Acetaminophen, a less potent pain reliever, enhances the effects of hydrocodone, making Norco a popular choice for managing moderate to severe pain. It is important to follow a healthcare provider's guidance when using this medication due to the potential for addiction and side effects.