Taking Oxycodone 5mg overnight can help alleviate pain and enhance sleep quality, but it's important to do so cautiously. Extended-release tablets are generally preferred for overnight use as they provide continuous relief for up to 24 hours. However, side effects such as drowsiness, dizziness, and slowed breathing may be more pronounced when lying down. Always follow your doctor's instructions and never exceed the prescribed dose. Abruptly stopping Oxycodone 5mg can lead to withdrawal symptoms, so always consult your healthcare provider before making any changes to your medication regimen.