Methadone is a prescription drug. It’s an opioid, which makes it a controlled substance. This means this drug has a risk of misuse and may cause dependence. Methadone comes as an oral tablet, oral dispersible tablet (tablet that can be dissolved in liquid), oral concentrate solution, and oral solution. Methadone also comes in an intravenous (IV) form, which is only given by a healthcare provider. Methadone is also available as the brand-name drug Methadose, which comes in an oral soluble tablet. Methadone oral tablet is used to manage moderate to severe pain. It’s only given when other short-term or non-opioid pain drugs don’t work for you or if you can’t tolerate them. Methadone is also used to manage drug addiction. If you have an addiction to another opioid, your doctor may give you methadone to prevent you from having severe withdrawal symptoms.