Opana, also known by its generic name oxymorphone, is a powerful opioid medication used for pain management. It has gained popularity for several reasons, both medically and unfortunately, recreationally: Potency: Opana is considered to be more potent than some other opioid medications like oxycodone or hydrocodone. This means that it can provide effective pain relief for individuals who have developed tolerance to less potent opioids.