Take Suboxone exactly as directed by your doctor, usually once daily, one hour before breakfast or one or two hours after breakfast. Depending on your medical needs, your doctor may adjust your dosage to small doses up to three times a day. Taking this late in the day may cause difficulty sleeping. If you are taking the extended-release capsules, you may need to take a dose once daily before breakfast or about 10 to 14 hours before bedtime.