Norco works as other opioids do the process such as the drug alters your response to pain by binding to opioid receptors in the CNS(central nervous system) and prevents the brain from receiving pain signals from the body.At the same time, this medication interacts with the brain’s reward system, releases dopamine, and induces euphoric feelings and deep relaxation. Because people are naturally hardwired to chase a dopamine rush, this is the reason opioids, including Norco, can be addictive.