Oxycodone 80 mg blue is an opioid analgesic used to treat moderate to severe pain, it changes how you feel pain by blocking pain signals in your body. Oxycodone works by activating opioid receptors in the nervous system, as it is an opioid agonist. Oxycodone is a prescription medicine used for moderate to severe pain when other pain medicines when do not work well enough, or are not tolerated. Oxycodone 80mg comes in slow-release tablets and also standard tablets, capsules, oral liquid or injections that work quickly. These faster acting forms are used as needed for acute (short-term) pain, and the extended-release tablets are used around the clock to treat severe and chronic pain that requires longer treatment. Extended-release products should not be used for as-needed pain relief.