Provigil is clinically proven to improve wakefulness and alertness. "Orexin," which is characterized as a sleep-inhibiting peptide, is involved in inducing excessive daytime sleepiness. Provigil promotes wakefulness by activating the orexin neurons in the brain's lateral hypothalamus. The proposed mechanism of Provigil (Modafinil) suggests that the Nootropic induces alertness through the alpha-adrenergic receptor. It inhibits the reuptake of noradrenalin, thus amplifying its signals between sleep-promoting neurons.