Vicodin is a prescription medication and a brand name for a combination of acetaminophen and hydrocodone. Hydrocodone is an opioid pain medication, while acetaminophen is a less potent pain reliever that enhances the effect of hydrocodone. Together, they effectively manage moderate to moderately severe pain. Hydrocodone bitartrate appears as fine white crystals or a crystalline powder sensitive to light, while acetaminophen is a slightly bitter, white crystalline powder.