https://bigpharmausa.com/methylprednisolone-vs-prednisone/ Methylprednisolone is more effective than prednisolone in mediating long-term cytolysis and immediate inhibition of nucleoside uptake in human lymphoblastoid cells. Methylprednisolone and prednisone are corticosteroids used to treat various inflammatory and autoimmune disorders, with methylprednisolone being slightly more potent than prednisone. Methylprednisolone and prednisone are both common medications that are similar in price. They can come in branded or generic forms. As with most drugs, the generic versions cost less but still comprise the same substances.