One opioid agonist that is utilized as an analgesic and antitussive is hydrocodone. Extended-launch forms of hydrocodone, such as Zohydro ER and Hysingla ER, can be used to treat severe pain 24/7. To manage mild to severe pain, it is typically used in combination with acetaminophen. It is not recommended to utilize extended-launch hydrocodone for pain on an as-wanted basis.