Percocet is a painkiller, so it’s important to follow your doctor’s instructions before taking it. Here are a few Points to keep in mind: Percocet should be taken orally with a full glass of water and swallowed whole. Dosage and frequency should be determined by a doctor based on the patient's condition and response to the medication. Do not crush, chew, or break the tablet, and do not increase the dosage or take it more frequently than prescribed. Store the medication in a secure place away from children and those who may misuse or abuse it. Percocet interactions with other drugs.