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Tramadol as a pain reliever Tramadol is a pain reliever that is prescribed by doctors to treat moderate or severe pain. It's usually taken without a prescription, and it can cause drowsiness. Doctors often recommend such medications for long-term use. However, a new study suggests that heavy users of this drug may be at a higher risk for depression and suicidal thoughts. Tramadol is a pain reliever that is prescribed by doctors to treat moderate or severe pain. It's usually taken without a prescription, and it can cause drowsiness. Doctors often recommend such medications for long-term use. However, a new study suggests Tramadol is a pain reliever that is often used for chronic pain or pain related to cancer. Its effects on the body are different from other pain relievers because it doesn't work by numbing the nerve endings, but instead works by counteracting the body's natural reaction to send chemical signals to the brain, reducing the perception of pain. 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