Users witnessing technical problems like outlook won't open in safe mode is common but one can easily resolve such issues by applying the steps. However, one of the annoying issues related to Outlook is responding error. To fix such issues, you are supposed to close Outlook and then you must start it in safe mode and then you should close it and then you must open it normally to resolve the issues. Now, you must close the Outlook and then you should launch Outlook in safe mode just by choosing the options. Apply the steps to resolve the issues.