What is Vicodin? Vicodin is an FDA-approved opioid pain medication that is a medicinal combination of hydrocodone and acetaminophen that binds the opioid receptors in the body to reduce pain signals. You can get the medicine online only if you hold an appropriate prescription from a doctor as it is a scheduled and approved drug; therefore, buying or selling Vicodin without a proper prescription is strictly prohibited in the court of law.