To estimate how long it takes for Xanax to be mostly cleared from your system, you can use the rule of thumb that it takes approximately 5 half-lives for a drug to be eliminated. So, for Xanax: This means that it can take around 56 hours, or roughly 2.3 days, for a 2mg dose of Xanax to be mostly cleared from your system. However, it's important to note that individual variations exist, and factors such as metabolism, age, liver function, and other medications can affect the clearance rate. Online buy Xanax fedex