Tumor markers appear along with tumors and are usually increased in amounts of proteins, oncogenes, tumor suppressor genes and their related products in the form of antigens, enzymes, receptors, hormones or metabolites. It is produced and secreted by tumor cells, or is part of the released tumor cell structure. It exists only in tumor cells and is often released into serum or other body fluids, which can reflect the presence of tumors in the body to a certain extent. The detection and analysis of tumor biomarkers is the core of personalized and precise tumor therapy, which can determine the occurrence, development and prognosis of tumors. Complete and comprehensive detection is of great significance for elucidating the effect of anti-tumor drugs or drug resistance mechanisms, and screening characteristic populations.