Percocet is an opioid-based pain medication that contains the active ingredient oxycodone. It binds to opioid receptors located in the brain, spinal cord, and other parts of the body to change the way pain is perceived. The opioid component of Oxycodone blocks pain signals. Acetaminophen enhances the effects of Oxycodone. Percocet can be used as an over-the-counter (OTC) painkiller. It is a powerful painkiller that can be used to relieve moderate-to-severe pain, especially after surgery or an injury. However, it can also lead to addiction, addiction, or overdose, especially when used for long periods or if abused or abused by the wrong person.