Does Nail Polish Remover Help With Armpit Stains? Nail polish remover is sometimes used to treat armpit stains on clothing, but it’s not generally recommended. The acetone in nail polish remover can damage delicate fabrics, fade colors, or leave its own marks on the material. Safer alternatives include using baking soda, white vinegar, or a hydrogen peroxide solution, which are effective at breaking down sweat stains without harming the fabric. Always test any treatment on a small, hidden area of the fabric first.