What is Ativan? Move a step forward, rebuild the calmness within you. Ativan, a member of the benzodiazepine family, works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain. This leads to a calming effect, making it effective for treating anxiety, anxiety-related insomnia, and certain seizure disorders. This neurotransmitter is responsible for reducing overactivity in the central nervous system (CNS). It acts like a natural "brake," helping regulate mood, anxiety, and neural excitability.