Circulating tumour cells (CTCs) is an uncommon type of cell seen in the blood of individuals with solid tumours and act as a seed for metastasis. Cancer spreads via the circulation in two ways: single migratory CTCs and multicellular groupings CTC clusters. CTCs are ideal for creating preclinical models, especially 3D organoid cultures, for drug screening, disease modelling, genome editing, and organoid biobanks. The increased need for preventative medicine and companion diagnostics, as well as the rising incidence of cancer, are driving the circulating tumor cells market forward.