Hydrocodone is a prescription opioid medication used to treat severe pain and as a cough suppressant. It is typically prescribed when other pain relievers are ineffective. Hydrocodone is available in combination with acetaminophen (e.g., Vicodin, Norco) or ibuprofen, and in extended-release forms like Zohydro ER and Hysingla ER for around-the-clock pain management.