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Because of the potential side effects, risks, and complications of opioids, and the body's increasing tolerance to opioids over time, these medications are most clearly indicated for treatment of short-term intense pain, such as acute postoperative pain. If used to treat pain for longer periods, close monitoring is essential.

pain medications are medically termed opioids, and may be referred to as painkillers. They are derived from opium or made synthetically. Some narcotic pain medications contain both opium-derived and synthetic material.

Over-the-counter (OTC) medicines are good for many types of pain. There are two main types of OTC pain medicines: acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs). Aspirin, naproxen (Aleve), and ibuprofen (Advil, Motrin) are examples of OTC NSAIDs.

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