Available Models of Common Age-Related Diseases Bone disease. For example, age-related bone loss, and age-related osteoporosis models. Cardiovascular diseases. For example, the primary hypertension animal model, myocardial infarction animal model, heart failure animal model, etc. Aging lung. Neurodegenerative disease. For example, models of Parkinson's disease and Alzheimer's disease. Multi-morbidity and frailty. For example, some chronic disease models include arthritis, diabetes, cancer, heart disease, and stroke. There are also frailty animal models.