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Nucleoside phosphoramidites are derivatives of natural or synthetic nucleosides that are used to synthesize oligonucleotides, relatively short fragments of nucleic acid and their analogs. Oligonucleotides are widely used in biological research as effective tools to regulate gene expression and have also been developed as therapeutics. Therapeutic oligonucleotides are usually modified to enhance their stability and specificity and to minimize the side-effects. They include antisense oligonucleotide, small interference RNA (siRNA), ribozyme (RNA enzymes) and deoxyribozymes (DNA enzymes), CpG oligodeoxynucleotides (CpG ODN), transcription factor decoys, and aptamers. In various oligonucleotide synthesis methods, the phosphoramidite method is the most preferred one as it best meets the criteria for viable synthesis of oligonucleotides. The synthesis approach is suitable for the synthesis of long oligonucleotides with modified backbones, which are difficult to prepared by other methods.

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